6/16/2023 0 Comments G protein linked receptorsG proteins are a family of intracellular proteins capable of mediating signal transduction pathways. More specifically, in nerve cells, along with ion transporters, they are responsible for maintaining the electrochemical gradient across the cell. Ion channels allow for the selective movement of certain ions across the plasma membrane in cells. Generally, G protein-gated ion channels are specific ion channels located in the plasma membrane of cells that are directly activated by a family of associated proteins. G protein-gated ion channels are a family of transmembrane ion channels in neurons and atrial myocytes that are directly gated by G proteins. (C) In other cases, the activated βγ-complex of the G protein may interact with the ion channel. (B) The GTP-bound α-subunit in some cases can directly activate the ion channel. 15 School of Pharmacy, Fudan University, 201203, Shanghai, China.Generalized diagram of G protein-gated ion channel: (A) Typically, the activated effector protein begins a signaling cascade which leads to the eventual opening of the ion channel. 14 School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China. 13 University of Chinese Academy of Sciences, 100049, Beijing, China. 12 School of Basic Medical Sciences, Fudan University, 200032, Shanghai, China. 11 The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China. 10 The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China. 9 The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China. 8 School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China. 7 iHuman Institute, ShanghaiTech University, 201210, Shanghai, China.15 School of Pharmacy, Fudan University, 201203, Shanghai, China. 6 School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China.5 iHuman Institute, ShanghaiTech University, 201210, Shanghai, China.4 University of Chinese Academy of Sciences, 100049, Beijing, China.3 School of Basic Medical Sciences, Fudan University, 200032, Shanghai, China.2 The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China.1 The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China.
0 Comments
Leave a Reply. |